primarily opioidergic and adenosine mechanisms are considered to be involved in the antinociceptive effects of antidepressants. this study was designed to determine the efficacy of acute venlafaxine administration in alleviating symptoms of neuropathic pain and the role of endogenous adenosine and opioid systems in this effect of venlafaxine. we have evaluated the effect of caffeine, a non-sele...

conclusions coq10 abolished neuropathic pain in cci rats. prevention of cell loss might be attributed to the analgesic effect of coq10. hence, it might be used as a therapeutic intervention for neuropathic pain. background oxidative stress contributes to neuropathic pain. coenzyme q10 (coq10) is used for the treatment of neurodegenerative diseases. however, there is no report regarding the ther...

background: neuropathic pain (np) is one of the most suffering medical conditions that often fail to respond to certain pain therapy. although its exact etiology is still unknown the role of reactive oxygen species (ros) and oxidative stress were explored by many researchers. neuropathies either central or peripheral lead to painful condition as well as social and economic isolation, thus vario...

introduction: rosemary, rosmarinus (r.) officinalis l. is a well-known plant with several useful properties such as analgesic, anti-inflammatory and anti-neurodegenerative. it has been used in folk medicine to alleviate rheumatic pain, stomachache and dysmenorrhea. rosemary has several constituents such as rosmarinic acid which can be responsible for therapeutic properties been noted with rosem...

OBJECTIVES To determine the differences in pupillary light reflex (PLR) between the acute and chronic phases of optic neuritis (ON) and nonarteritic anterior ischemic optic neuropathy (NAION). METHODS The study included 30 patients with ON and 22 patients with NAION whose PLR were measured by a dynamic pupillometer (PLR-200; NeurOptics Inc., Irvine, USA). Age-matched controls included 58 heal...

Chronic obstructive pulmonary disease (COPD) is characterized by tissue loss and a growing restriction of airflow. Due to chronic inflammation brought on extended exposure noxious particles or gases, most often cigarette smoke, it linked structural abnormalities in the lungs. Airway constriction reduction lung recoil are results inflammation. In affluent countries, majority COPD cases caused to...

Chronic constriction injury to the sciatic nerve was used as an animal model of neuropathic pain. Instead of frequently used reflex-based tests we used an operant thermal place preference test to evaluate signs of neuropathic pain and the effect of baclofen administration in rats with neuropathy. Chronic constriction injury was induced by four loose ligations of the sciatic nerve. Thermal place...

Constrictive pericarditis — Constrictive pericarditis is the result of scarring and consequent loss of the normal elasticity of the pericardial sac. Pericardial constriction is typically chronic, but variants include subacute, transient, and occult constriction. Pathologically, this results in chronic inflammation and, frequently, calcification. Grossly, the pericardium is considerably thicker ...